Our research programmes have focused on using international research frameworks to mobilise discovery and evaluation of risk factors for prediction of disease, reporting epigenetic disturbances and translating evidence-based interventions for NCDs into the Indian context. Indians are at ~3-fold higher risk of type-2 diabetes (T2D) and Cardiovascular Disease (CVD), compared to Europeans. This excess risk is not explained by known risk factors. Our main research interest is to identify potential causal associations, and help establish new approaches to risk stratification, early interventions, prevention and management of T2D and CVD.