Covid-19

COVID-19 infection presenting with a cerebrovascular accident (stroke) upto 5 to 6% different studies. Its seen more commonly who has  severe infection and associated Co Morbid condition which are similar to lung syndromes  like advancing age  Diabetes  Hypertension Coronary artery disease ,though certain young persons have also presented first time with stroke based on US Studies.

Clinicians should investigate all unusual stroke or even heart attacks with possible link of COVID 19 infection. Blood tends be thicker with severe infection which results in small or larger clot which may cause sudden blockages of blood supply to part of the brain and they can present with weakness or paralysis of body.

Diabetes is well known to increase risk of stroke or CVD (Cardiovascular disease) by 2-3 times and most early deaths in Diabetes are due to CVD . I am not surprised that patients with Diabetes are presenting with stroke or heart attacks though these are not commonly seen at our centre.

COVID-19 (1)

Covid-19 Research

In view of the current pandemic, our team has taken an initiative and devised five projects aimed at different perspectives of COVID-19 but are inter-linked. Our studies have been registered on the Clinical Trials Registry of India (CTRI) portal, and data will be shared with the Indian Council of Medical Research (ICMR) as soon as we get a good number of responses. Our observational study on healthcare workers is the first project of its kind in India to be registered with the CTRI and the first study on Clinicaltrials.gov from India. It is a non-funded, Max Healthcare only survey, which so far, has had participation from 4300 plus healthcare workers. We are hoping to project even more responses in the coming weeks. Our COVID research team comprises of around 50 researchers.

 The specific COVID-19 projects are as below-

 1. Prospective longitudinal, observational study to screen healthcare workers for flu-like or COVID-19 symptoms

https://clinicaltrials.gov/ct2/show/NCT04339608?term=flu-like&draw=3&rank=15

 2. Prospective longitudinal, observational study to screen the general population for flu-like or COVID-19 symptoms

 3. A prospective, longitudinal, observational study to assess the seroconversion status of front line Health Care workers and comparison with the suspected or confirmed cases of COVID-19 patients at Max Health Care

https://clinicaltrials.gov/ct2/show/NCT04368884?term=Seroconversion&draw=2&rank=7

 4. COVID19: Knowledge, Practices and Impact in South Asia (NGHRU sub-study)

 5. Assessing the correlation of QTC interval and Hydroxychloroquine intake in healthcare workers

We have designed a survey for all the healthcare workers of Max Hospitals as well as the general population to screen and track for COVID-19 or flu-like symptoms. The survey includes information on the health status, clinical symptoms, prophylaxis, information on using Personal Protective Equipments (PPE) by the healthcare workers and social impact of COVID-19 on the general population. Anybody can voluntarily participate in this study to inform about their symptoms or the absence there of. They can also ask their family members and loved ones, who may or may not be showing symptoms to fill this up and help Max Healthcare in this initiative. The main aim is to reach out to maximum number of people, monitor symptoms and understand the disease pattern.

 As for the general public, currently we are sending the form via the same media, to known people of our employees, to the RWAs, PSUs, and other related contacts. So far, we have received ~1000 responses in four days and expecting many more. We are also working on developing an application by the means of which everyone will have access to these forms.  The survey will continue till the pandemic ends, as apart from tracking and screening, we are also working towards understanding the behavior of the virus which will further help in the study of it’s nature and long-term effects.”

 We would be very grateful if, in this critical period, people could spare some of their valuable time to share their health status and contribute towards the prevention of further spread of this disease. Also, this is a form of surveillance, in case anyone has any symptoms please contact the local or central government authorities and follow the Health Ministry guidelines.

 (Link for the survey for general population):-

ENGLISH:

Part 1: https://www.research.net/r/Data_Collection_Form_COVID_19

Part 2: https://www.research.net/r/PART-II_DASS21

 HINDI:

भाग 1: https://www.research.net/r/Hindi_Data_Collection_Form_COVID-19

भाग 2: https://www.research.net/r/Hindi-Part-II_DASS21

 A large number of Health Care Workers (HCWs) would be potentially getting exposed to COVID19. Some of them would be asymptomatic or may get subclinical symptoms. Our HCW cohort at Max Hospital, Saket in Delhi, would have higher exposure and possibly higher seroconversion either symptomatic or with clinical symptoms than the general population. One of our study design will focus on the cohort population of HCW and the confirmed cases of COVID-19 admitted at Max. This study is aimed to understand the rate of seroconversion states at different stages of exposure. It is crucial to collect baseline immune status and the early immunological changes that might occur in asymptomatic or symptomatic health care workers and to compare that with the suspected or confirmed cases by following them for six weeks. We will be storing the samples of the study participants as per the ICMR policy, until we procure funding for the analysis which will include immunological and genetic markers.

 Our GHRU cohort is also being followed up telephonically and we are getting a digital questionnaire filled which includes the social, mental and economic impact of COVID-19 on the community across the South Asia.

 Also, we are doing 3-lead ECG of the HCWs who are taking Hydroxychloroquine as prophylaxis to see if there is any correlation of QTC prolongation and the drug. Our research team of team is fully protected in PPE while collecting the data, performing ECG or collecting blood sample and following all the ICMR guidelines.